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Primal Gut™ is a blend of 13 probiotic strains designed to work synergistically and proven by research to be safe and effective in supporting your microbiome when used with a healthy, real food diet.
Here's a glimpse of what these strains can do for you...
Lactobacillus rhamnosus - Perhaps one of the most prominent Lactobacillus bacteria in the gut, research states L. rhamnosus supports a strong respiratory systemhelps keep inflammation in check, and encourages a healthy intestinal lining.*1 It has also been used in protocols for children and adults with diarrhea.*2
Lactobacillus acidophilus – L. acidophilus is one of the most common probiotic in supplements and foods like yogurt. It produces lactic acid and hydrogen peroxide that some troublesome bacteria don't like. By doing so, it seems to help keep the community of microbes in your intestines healthy and balanced. Clinical research has linked L. acidophilus to keeping the urogenital tract healthy and to supporting immune system strength.* One clinical study showed L. acidophilus helped schoolchildren make it through the winter with less absences.*3
Lactobacillus plantarum - No less than four clinical trials have shown that L. plantarum helps support comfortable digestion – helping to minimize gas, bloating, and abdominal pain.*4 One of the most common probiotics, L. plantarum seems to help regulate your immune response, reducing inflammation in the body*. Not only does L. plantarum stimulate the production of anti-inflammatory cytokines like IL-10, it also seems to stimulate the production of regulatory T-cells.*5
Preliminary studies indicate that L. plantarum may help you strengthen your memory, concentration and improve your mood.*6 7
Lactobacillus paracasei - L. paracasei have been shown to support comfortable digestion in a number of ways, including by helping to regulate inflammation. It's also been linked to healthy cholesterol levels, healthy blood pressure and a balanced, strong immune system.*8
In a 2014 study on 34 healthy individuals, researchers found that supplementing with L. paracasei not only added this helpful bacteria to your intestine . . . but also seemed to shift the composition of the microbial population overall in their intestines. L. paracasei seemed to move the entire microbiome towards species associated with good health.*9
Lactobacillus gasseri - L. gasseri has been shown in at least two clinical trials to help people lose weight. In a 2013 trial published in the British Journal of Nutrition, participants who supplemented with L. gasseri lost at least 8% of their abdominal fat over the course of 12 weeks.*10 Research is still ongoing on the exact mechanism, but it seems L. gasseri interferes with fat absorption.11 Preliminary research indicates that L. gasseri may inhibit inflammation signaling at the genetic level!*12
L. gasseri have been shown in studies to help your body regulate cholesterol levels in the blood.*13
Lactobacillus salivarius - Several clinical trials on both adults and children indicate that L. salivarius seems to help regulate the immune system and - as a result - support healthy skin.*14 It's also been researched for potential support in keeping the vagina healthy and comfortable.*15 L. salivarius also seems to play a distinct role in keeping the microbial population in your mouth healthy. *16
Lactobacillus brevis – First isolated from a traditional Japanese pickle, L. brevis is found in many fermented foods. Dr. David Perlmutter, author of Brain Maker, considers it one of the core probiotics we all need for good health. He points out that it seems to support healthy brain growth by increasing production of the brain growth hormone, BDNF. 17 Clinical research suggests it also helps with intestinal health and immune strength.* Preliminary research indicates it can trigger an increase in production of interferon in the body and enhance activity of killer T cells.18 One large-scale clinical study showed it seemed to make a significant difference in keeping children healthy over the winter season.*19 Some clinical research also suggests it can help support vaginal comfort and health by adhering to vaginal walls and making it an unfriendly environment for more troublesome microbes.*20
Bifidobacterium infantis – B. infantis is the primary microbe in infant guts. It seems to play a critical role in establishing a healthy intestinal lining and a strong and well-regulated immune system.*21 But its work doesn't end with infancy. Research has also linked it to helping mitigate inflammation in the digestive system and throughout the body.* In three different studies, B. infantis seemed to reduce the production of inflammatory cytokines, signaling the immune system to cool off.*22 When it comes to your brain, B. infantis also plays a role. Research suggests B. infantis regulates the production of tryptophan which is the precursor for serotonin.Serotonin is the neurotransmitter associated with a sense of satisfaction and happiness. *23
Bifidobacterium breve - B. breve has been linked to helping with childhood constipation.*24 And when combined with a gluten-free diet, B. breve can help restore microbial balance in the digestive tract of children who have experienced some intestinal inflammation.*25 B. Breve seems to play a particular role in helping to establish a healthy microbiome . . . A few clinical trials involving pre-term babies demonstrate it works particularly well in getting their gut back in shape. 26 Clinical research suggests this special bacterium is particularly effective in recolonizing the gut of children who have undergone chemotherapy.*27 The children who took this probiotic seemed to recover better from the treatment without any complications that are usually associated with chemotherapy.
Bifidobacterium longum - One of the first bacteria to colonize our bodies at birth, B. longum has been associated with helping to digest milk and other challenging foods. 28 A placebo-controlled clinical study on 33 children with some digestive discomfort showed that in combination with a gluten-free diet, B. longum not only helped them grow taller but also showed some indications of keeping their immune system strong and balanced.*29 B. longum has also been linked to helping you maintain healthy cholesterol levels.*30
Bifidobacterium lactis - In one eye-opening study, when pre-term babies were given B. lactis after taking antibiotics, they gained an amazing four times as much weight as the babies given the placebo. And interestingly, these babies gained more weight even though they consumed less milk!* In this same study, researchers observed signs that B. lactis helped the babies' immune systems develop effectively.*31 But this bacterium isn't just for babies . . . Extensive research has shown that B. lactis is a superstar when it comes to abdominal comfort and good digestion. It seems to help get your colon in shape and make constipation a thing of the past. *32Finally - and significantly – preliminary lab research indicates B. lactis shows exciting promise in neutralizing certain toxins from wheat.* 33
Bifidobacterium bifidum – A 2015 clinical study published in the British Journal of Nutrition showed B. bifidum helped academically stressed college students make it through the winter semester. The students who took B. bifidum had much fewer absences than the students who didn't take the probiotic. 34 Another clinical study indicates B. bifidum may help with abdominal discomfort, gas and bloating.*35 And a recent randomized placebo-controlled study also showed that B. bifidum can help with stress-related diarrhea.*36 Finally, clinical research published in May, 2016 Journal of Rheumatic Diseases suggests that B. bifidum can help you maintain comfortable joint movement by helping your body manage inflammation.*37
As you can see, Primal Gut™ gives you a carefully selected mix of probiotics, proven to bring healthy results.
1 Segers ME et al. Towards a better understanding of Lactobacillus rhamnosus GG - host interactions. Microbial Cell Factories. 2014;13(Suppl 1):S7. doi:10.1186/1475-2859-13-S1-S7.
2 Lactobacillus Acidophilus. University of Maryland Medical Center website. Viewed 2/22/17 at http://umm.edu/health/medical/altmed/supplement/lactobacillus-acidophilus
3 Lactobacillus Acidophilus. University of Maryland Medical Center website. Viewed 2/22/17 at http://umm.edu/health/medical/altmed/supplement/lactobacillus-acidophilus
4 Ducrotté P et al. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World Journal of Gastroenterology : WJG. 2012;18(30):4012-4018.
5 Ferreira dos Santos T et al. Immunomodulatory Effects of Lactobacillus plantarum Lp62 on Intestinal Epithelial and Mononuclear Cells. BioMed Research International. 2016
6Jeong JJ et al. Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent memory impairment in Fischer 344 rats. Lett Appl Microbiol. 2015 Apr;60(4):307-14. doi: 10.1111/lam.12393. Epub 2015 Feb 4.
7 Li H et al. Lactic acid bacterial cell factories for gamma-aminobutyric acid. Amino Acids. 2010 Nov;39(5):1107-16. doi: 10.1007/s00726-010-0582-7. Epub 2010 Apr 3.
8 Chiang, SS et al. Beneficial effects of Lactobacillus paracasei subsp. paracasei NTU 101 and its fermented products. Appl Microbiol Biotechnol (2012) 93: 903.
9 Harrison-Dunn, AR. L. Paracasei May Shift Intestinal Microbiota in Healthy People. Nutraingredients Sept 7, 2014.
10 Kadooka Y et al.Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr. 2013 Nov 14;110(9):1696-703.Epub 2013 Apr 25.
11 Ogawa A et al. Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects. Lipids in Health and Disease. 2015;14:20.
12 Miyoshi M et al. Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice.Eur J Nutr. 2014;53(2):599-606. doi: 10.1007/s00394-013-0568-9. Epub 2013 Aug 6.
13 Ooi, L.-G. et al. Lactobacillus acidophilus CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters. Journal of Dairy Science , Volume 93 , Issue 11 , 5048 - 5058
14 Drago L et al. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex: a pilot study on adults.J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S47-51.
15 Mastromarino P et al. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clinical Microbiology And Infection. 15 (1) January 2009.
16Haukioja A. Probiotics and Oral Health. European Journal of Dentistry. 2010;4(3):348-355.
17 Perlmutter D. 5 Core Species Of Probiotics. Viewed 2/10/17 at http://www.drperlmutter.com/learn/resources/probiotics-five-core-species/
18 Waki, N. et al. Oral administration of Lactobacillus brevis KB290 to mice alleviates clinical symptoms following influenza virus infection. Lett Appl Microbiol, 2004. 58: 87–93.
19 Waki N et al. Effects of probiotic Lactobacillus brevis KB290 on incidence of influenza infection among schoolchildren: an open-label pilot study. Letters in Applied Microbiology. 2014;59(6):565-571.
20 Mastromarino P et al. Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clinical Microbiology And Infection. 15 (1) January 2009.
21 Underwood MA et al. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research. 2015;77(0):229-235.
22 Groeger D et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 2013;4(4):325-339.
23 L. Desbonnet et al., "The Probiotic Bifidobacteria infantis: An Assessment of Potential Antiidpressant Properties in the Rat," J. Psychiatr. Res. 43, no. 2 (December 2008): 164-74.
24 Tabbers M et al. Is Bifidobacterium breve effective in the treatment of childhood constipation? Results from a pilot study. Nutrition Journal. 2011;10:19.
25 Duque Braga TD et al. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial. Am J Clin Nutr 2011 93: 1 81-86; First published online October 27, 2010.
26 Quagliariello et al. Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study. Nutrients. 2016;8(10):660.
27 Yamashiro Y et al. Beneficial microbes for premature infants, and children with malignancy undergoing chemotherapy. Benef Microbes. 2010 Nov;1(4):357-65.
28 Perlmutter D et al. Brainmaker. Little, Brown & Company. p. 210
29 Olivares M et al. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. Br J Nutr. 2014 Jul 14;112(1):30-40. doi: 10.1017/S0007114514000609. Epub 2014 Apr 28.
30 Xiao JZ, Kondo S, Takahashi N, Miyaji K, Oshida K, Hiramatsu A, Iwatsuki K, Kokubo S, Hosono A. Effects of Milk Products Fermented by Bifidobacterium longum on Blood Lipids in Rats and Healthy Adult Male Volunteers. J. Dairy Sci. 2003;86:2452–2461
31 Mohan R et al. Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants. Pediatric Research (2008) 64, 418–422.
32AGRAWAL, A. et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Alimentary Pharmacology & Therapeutics, (2009) 29: 104–114.
33 Lindfors K et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clinical and Experimental Immunology. 2008;152(3):552-558.
34 Langkamp-Henken B et al.Bifidobacterium bifidum R0071 results in a greater proportion of healthy days and a lower percentage of academically stressed students reporting a day of cold/flu: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2015 Feb 14;113(3):426-34.Epub 2015 Jan 21.
35 Guglielmetti S et al.. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life: a double-blind, placebo-controlled study. Alimentary Pharmacology and Therapeutics, Wiley, 2011, 33 (10), pp.1123.
36 Culpepper T et al. Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial. Benef Microbes. 2016 Jun;7(3):327-36. doi: 10.3920/BM2015.0156. Epub 2016 Feb 3.
37Zamani B et al. and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016 Sep;19(9):869-79.Epub 2016 May 2.