Contains a blend of ingredients involved in the synthesis and activity of GABA, a neurotransmitter important for sleep*
We aim to process and ship orders same day where possible. Please note all orders received after 3.30 pm on a Monday to Thursday will be processed and sent out the next working day.
Friday orders after 3.30pm will be shipped on the following Monday. For next day courier delivery orders must be received by 1.00pm.
For orders placed on Friday before 1.00pm requiring a next day courier you have 2 options; Next Day Saturday which incurs a premium charge or Next Day Standard which will be delivered on the following Monday.
Orders placed after 1.00pm via the courier option will be processed on Monday for Tuesday delivery.
Please note we do not process orders on Saturdays, Sundays or Bank Holidays.
GABA is the primary inhibitory neurotransmitter in the brain, meaning its central role is to balance excitability of neurons (1). Because of its function, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5).
Ingredients such as taurine and vitamin B6 are important for glutamate-GABA balance.* High glutamate can damage neurons, alter cellular homeostasis, and cause mitochondrial dysfunction, which can ultimately lead to cell death (6). Taurine demonstrates GABA-A agonist activity and protects neurons and mitochondria against glutamate-induced damage (6,7).* Active form of vitamin B6 is important for the synthesis of GABA as it is a required cofactor for glutamate decarboxylase, the enzyme responsible for converting glutamate to GABA (8-10).*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
2. Mohler H. Neuropharmacology. 2012;62(1):42-53.
3. Saper C, et al. Nature. 2005;437(7063):1257-63.
4. Mody I and Maguire J. Front Cell Neurosci. 2012;6:4.
5. Maguire J. Front Cell Neurosci. 2014;8:157.
6. Ye H, et al. Can J Neurol Sci. 2013;40(5):628-34.
7. Kletke O, et al. PLoS One. 2013;8(4):e61733.
8. Rowley N, et al. Neurochem Int. 2012;61(4):546-58.
9. Martin D. Cell Mol Neurobiol. 1987;7(3):237-53.
10. Mukherjee T, et al. Biochim Biophys Acta. 2011;1814(11):1585-96.
|Serving Size: 2 Capsules|
|Servings Per Container: 60|
|Amount Per Serving|
|Vitamin B6 (as pyridoxal 5'-phosphate)||2 mg|
Taurine and 4-amino-3-phenylbutyric acid HCI
Microcrystalline cellulose, Vegetable capsule (Hypromellose, water), and Magnesium stearate (vegetable source).
Consult your healthcare provider before taking with sedatives.
If you are pregnant or nursing, consult your healthcare provider before use.
Take 1-2 capsules at bedtime as needed or as directed by your healthcare provider. Do not exceed suggested use.