We aim to process and ship orders same day where possible. Please note all orders received after 3.30 pm on a Monday to Thursday will be processed and sent out the next working day.
Friday orders after 3.30pm will be shipped on the following Monday. For next day courier delivery orders must be received by 1.00pm.
For orders placed on Friday before 1.00pm requiring a next day courier you have 2 options; Next Day Saturday which incurs a premium charge or Next Day Standard which will be delivered on the following Monday.
Orders placed after 1.00pm via the courier option will be processed on Monday for Tuesday delivery.
Please note we do not process orders on Saturdays, Sundays or Bank Holidays.
Support Liver was designed to support the two phases of liver detoxification.
The liver transforms fat-soluble toxins into a water-soluble form so they can be released through the kidneys (for elimination through the urine) and into the bile (for elimination through the colon). This transformation occurs during a two-phase process:
Phase I involves a group of 50 to 100 enzymes called the cytochrome P448 and P450 systems. These enzymes play a central role in the detoxification of both exogenous components (such as drugs and pesticides) and endogenous ones (such as hormones), as well as in the synthesis of steroid hormones and bile acids.
A side effect of this metabolic activity is the production of free radicals, which bind to cellular components and cause cellular damage. The most important antioxidant for neutralizing these free radicals is glutathione, which is needed both for Phase I and Phase II. When exposure to high levels of toxins produces so many free radicals from Phase I detoxification that all the glutathione is exhausted, Phase II processes dependent on glutathione cease. This causes an imbalance between Phase I and Phase II activity, which results in severe toxic reactions, due to buildup of toxic intermediate forms.
Phase II detoxification involves conjugation, which means that a protective compound becomes bound to the toxin. Besides glutathione conjugation there are essentially five other processes: amino acid conjugation, methylation, sulfation, sulfoxidation, acetylation and glucuronidation. These enzyme systems need specific nutrients in order to function. If the liver cells are not functioning properly, phase II detoxification slows down and increases the toxic load by allowing the buildup of toxic intermediates.
As explained below, Support Liver contains the ideal amounts of specific nutrients to support this phase, as well as phase I.